Comparison of Hydroxocobalamin Versus Norepinephrine Versus Saline in a Swine Model of Servere Septic Shock

Abstract

Sepsis is associated with a mortality of nearly 30%. Mortality is due, in part, to anuncontrolled inflammatory response. Matrix metalloproteinase-9 (MMP-9) and heat shockprotein 70 (HSP 70) have been suggested to be biomarkers of severe sepsis and may be usefulindicators of treatment success. Hydroxocobalamin (HOC), which regulates inducible nitricoxide synthase and increases systemic vascular resistance, may be effective in treating sepsisinducedhypotension and reversing overexpression of inducible nitric oxide synthase.Objective: To compare efficacy of HOC versus norepinephrine (NOR) ve r sus saline in swine withlipopolysaccharide (LPS)-induced endotoxemia.

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Document Details

Document Type
Technical Report
Publication Date
May 20, 2016
Accession Number
AD1012690

Entities

People

  • Joseph K Maddry
  • Maria G. Castaneda
  • Normalynn Garrett
  • Susan M. Boudreau
  • Vikhyat S Bebarta

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Agreements
  • Air Force
  • Animals
  • Arteries
  • Biomedical Research
  • Department Of Defense
  • Digital Information
  • Education
  • Hemorrhagic Shock
  • Infusions
  • Intellectual Property
  • Laboratory Animals
  • Materials
  • Norepinephrine
  • Sepsis
  • Technical Information Centers

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.