Identification of Androgen Receptor-Specific Enhancer RNAs
Abstract
The major goal of this application is to determine whether prostate cancer cells express enhancer RNAs in response to androgen treatment such that these enhancer RNAs may serve as novel biomarkers for prostate cancer diagnosis and prognosis. There are two Tasks in this application. First, we will perform global run-on assay and deep sequencing to identify AR-specific enhancer RNAs. Second, we will validate them and then determine their functional significance. The success of this study may lead to novel clinical applications such as identification of biomarkers or therapeutic targets for prostate cancer, especially for castration resistant prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2016
- Accession Number
- AD1012719
Entities
People
- Yin-Yuan Mo
Organizations
- University of Mississippi Medical Center