A Case of Acquired Pulmonary Alveolar Proteinosis Successfully Treated with Whole Lung Lavage

Abstract

Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of surfactant within the alveoli. Surfactant phospholipids and proteins are produced by type II alveolar epithelial cells, and subsequently cleared by the alveolar macrophages. Cell signaling initiated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor is essential to the breakdown of surfactant. The acquired form of PAP most commonly involves circulating anti-bodies to GM-CSF, with resultant accumulation of surfactant.

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Document Details

Document Type
Technical Report
Publication Date
May 18, 2016
Accession Number
AD1012760

Entities

People

  • Charles W. Borders
  • Julie Morgan

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Digital Information
  • Diseases And Disorders
  • Education
  • Epithelial Cells
  • Intellectual Property
  • Laboratory Animals
  • Lung Diseases
  • Macrophages
  • Materials
  • Surface Active Substances
  • Technical Information Centers

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology and Biomarker-Based Cancer Detection.