The Regenerative Response of Endogenous Neural Stem/Progenitor Cells to Traumatic Brain Injury
Abstract
The complex pathological mechanisms following traumatic brain injury (TBI) limit repair of damaged tissue. Cell signaling molecules have the potential to create a supportive environment for regeneration after injury. and promote the regenerative response from endogenous cells. Sonic hedgehog (Shh) has been shown to maintain neural stem cells (NSCs) and promote oligodendrogenesis. This study examines the influence of Shh signaling on neuronal (DCX) or oligodendroglial (NG2) progenitor responses, in either gray (GM) or white matter (WM) TBI models. A WM injury model in C57BL/6J mice was characterized at the coronal level of the subventricular zone (SVZ) to compare the response of Shh-responsive-NSCs following WM and GM injury. Analysis during the first week post-injury showed a) axon damage, neuroinflammation, demyelination. and redundant myelin figures in the corpus callosum (CC), b) an increase in NG2 cell proliferation in the SVZ and CC, and c) an increase in >JG2 cells in the CC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 09, 2014
- Accession Number
- AD1012867
Entities
People
- Genevieve M. Sullivan
Organizations
- Uniformed Services University of the Health Sciences