Effect of Solid Lipid Nanoparticle-Encapsulated Antimicrobial Peptide on Keratinocyte Migration and Wound Healing

Abstract

Objective: This study evaluated the effect of various drug delivery formulations on human keratinocyte migration and viability following treatment with the synthetic antimicrobial peptide KSL-W alone, KSL-W encapsulated in solid lipid nanoparticle (KSL-W + SLN), or solid lipid nanoparticles (SLN) alone evaluated by electric cell substrate impedance sensing (ECIS) (Applied Biophysics), photographic analysis and cell viability.

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Document Details

Document Type
Technical Report
Publication Date
May 03, 2013
Accession Number
AD1012900

Entities

People

  • Nathaniel B. Caldon

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Cell Count
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Infection
  • Microbiology
  • Pathogenic Bacteria
  • Three Dimensional
  • Tooth Diseases
  • Wound Infections

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Molecular and Cellular Biochemistry
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech