Identification of the GnRH-(1-5) Receptor and Signaling Pathway

Abstract

The decapeptide gonadotropin-releasing hormone (GnRH) is a central regulator of pubertal onset and reproductive function. In mammals, GnRH is released into the medianeminence of the hypothalamus to stimulate the pituitary release of the gonadotropins. Inturn, these hormones regulate the gonadal production of steroid hormones, which act as feedback modulators of the GnRH neuroendocrine system. Developmental defects in this regulation can lead to hypogonadotropic hypogonadism where the onset of puberty and fertility are impaired. Such is the case in patients suffering from Kallmann Syndrome (KS) where GnRH neurons emanating from the olfactory placode during development do not reach their destination within the central nervous system. Despite ongoing research in this field, a complete molecular understanding in the development of KS remains elusive.

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Document Details

Document Type
Technical Report
Publication Date
Mar 22, 2013
Accession Number
AD1013003

Entities

People

  • Darwin O. Larco

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Amino Acids
  • Brain
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Growth Factors
  • Nose
  • Organic Chemistry
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Speech Processing/Speech Recognition.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.