GABAA Receptor-Mediated Activity in a Model of Cortical Dysplasia

Abstract

Cortical dysplasia is a developmental abnormality characterized by changes in the structure and function of the neocortex. This disorder is implicated in many neuropsychiatric disorders such as epilepsy, autism and schizophrenia, and results from failure of immature neurons to appropriately migrate to their cortical targets. We developed a model of cortical dysplasia by administering methylazoxy methanol (MAM), an anti-mitotic, to pregnant ferrets on gestational day 33 leading to abnormal cortical layering, increased expression of GABAA receptors (GABAAR) and altered distribution of neurons derived from the ganglionic eminence (GE).

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Document Details

Document Type
Technical Report
Publication Date
Jun 29, 2012
Accession Number
AD1013067

Entities

People

  • Joseph Abbah

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Birds
  • Brain
  • Cell Division
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Epilepsy
  • Genetics
  • Information Processing
  • Neurons
  • Neurosciences
  • Peptide Growth Factors
  • Proteins
  • Stem Cells

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience