Protection by Purines in Toxin Models of Parkinson's Disease

Abstract

During the reporting period we have made substantial progress toward our main purpose of characterizing the mechanisms and neuroprotective potential of purines adenosine, caffeine, and urate -- linked to better outcomes in Parkinsons disease (PD), and toward all three of the original Specific Ams (SAs). Major accomplishments included a definitive demonstration that caffeines neuroprotective effect in a toxin model of PD requires the adenosine A2A receptor, and conversely that a transgenic alpha-synuclein model of PD also requires the A2A receptor (SA 1). We also discovered that a mutation in the gene encoding the urate-metabolizing enzyme urate oxidase (UOx) raised brain levels of urate and protected mice in another toxin model of PD, supporting the neuroprotective potential of targeting urate elevation in PD (SA 2).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2016
Accession Number
AD1013341

Entities

People

  • Michael A Schwarzschild

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Neurodegeneration
  • Organic Chemistry

Fields of Study

  • Biology

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Prostate Cancer Biology.
  • Theoretical Analysis.