Activation of mTor Signaling by Gene Transduction to Induce Axon Regeneration in the Central Nervous System Following Neural Injury (Addendum)

Abstract

A long-standing belief about injuries and diseases of the brain and spinal cord has been that once axons are destroyed, they will not re-grow. This belief is now being challenged. As the brain matures, the genetic programs that control axon growth during development are silenced. Recent evidence shows that re-activation of these programs in the adult successfully induces axon growth. We have shown that re-activation of Akt/mTORC1 signaling, by use of AAV vector transfer, induces regrowth of dopaminergic axons at 3 to 6 weeks after destruction by a neurotoxin. However, this approach cannot be used inhumans because Akt/mTORC1 signaling is oncogenic. The goal of this proposal is to refine this approach to achieve restorative effects in the absence of adverse effects.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2016
Accession Number
AD1013357

Entities

People

  • Robert E Burke

Organizations

  • Columbia University Irving Medical Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Brain
  • Carrier Proteins
  • Cellular Structures
  • Central Nervous System
  • Confocal Microscopy
  • Diseases And Disorders
  • Dopamine
  • Gene Therapy
  • Immunostaining
  • Nervous System
  • Neural Pathways
  • Neurons
  • Neurosciences
  • Parkinson'S Disease
  • Proteins

Readers

  • Defense Acquisition Program Management
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology