Neurogenin1 Expression and Function in the Developing Mouse Cerebellum
Abstract
The basic helix-loop-helix (bHLH) transcription factors Ptf1a and Math1 are necessary for the specification of gamma-aminobutyric acid (GABA)-ergic andglutamatergic cell lineages in the cerebellum, respectively. Recent evidence suggests that cascades of bHLH factor activities drive cell type specificity in Ptf1a-positive and Math1-positive lineages. Neurogenin1 (Neurog1) is a bHLH transcription factor involved in the development of several nervous system structures including the cerebral cortex, trigeminal sensory neurons, inner-ear sensory neurons, and olfactory sensory neurons. Recently, expression of Neurog1 has been reported to be co-expressed in Ptf1a expressing cells in the ventricular zone (VZ) of the developing cerebellum, suggesting a role in subtype specification of GABAergic progenitor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 14, 2011
- Accession Number
- AD1013358
Entities
People
- Travis G. Lundell
Organizations
- Uniformed Services University of the Health Sciences