Structure Function Analysis of the Ferric Uptake Regulator (Fur) of Helicobacter pylori
Abstract
Helicobacter pylori is a Gram negative, microaerophilic, spiral shaped bacterium that is the causative agent of gastritis and peptic ulcer disease and is implicated in the development of both mucosa-associated lymphoid tissue (MALT) lymphoma and gastric adenocarcinoma. H. pylori expresses several factors that aid in its colonization of and persistence within the harsh environment of the stomach. Among these factors is the Ferric Uptake Regulator (Fur). Fur traditionally represses genes by binding to select regions within target promoters (Fur boxes) in its iron-bound dimeric form, which results in the occlusion of the RNA polymerase binding site. This type of iron-bound Fur repression is utilized in H. pylori as well as widely in the bacterial world.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 17, 2010
- Accession Number
- AD1013395
Entities
People
- Beth M. Carpenter
Organizations
- Uniformed Services University of the Health Sciences