Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans

Abstract

There is striking disparity in prostate cancer incidence and mortality for African American men as compared to Caucasian Americans. The objective of this proposal is to determine associations and racial differences in the distribution of key clinico-pathologic patient features and molecular determinants for both ERG positive and ERG negative prostate cancer. It is anticipated that molecular determinants of aggressive prostate cancer in African American men, including somatic mutations and SNPs associated with prostate cancer risk, may associate with ERG fusion negative prostate cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1013482

Entities

People

  • Gyorgy Petrovics

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • African Americans
  • Caucasians
  • Data Analysis
  • Disparities
  • Ethnic Groups
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Medical Personnel
  • Military Medicine
  • Mutations
  • Neoplasms
  • Prostate Cancer
  • Regression Analysis
  • Statistical Analysis
  • Tissues

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.