Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy
Abstract
We are evaluating, in two nested case-control studies, intraprostatic inflammation and focal atrophy, a prostate lesion that is often inflamed, as tissue markers for risk of future diagnosis of total and high-grade prostate cancer, and for prognosis at the time of surgery for clinically localized prostate cancer. For prostate cancer incidence, in Year 3, we completed the statistical analysis of the pathology review of inflammation and focal atrophy the H and E stained biopsy core images for the linked PCPT-SELECT data (incident prostate cancer). We found that the odds of low-grade prostate cancer tended to increase with the number of biopsy cores with inflammation. For prostate cancer recurrence, we used an optimized higher-throughput method for image analysis to evaluate in the Brady nested case-control recurrence set the association between mast cell density and recurrence risk. We found that greater mast cell density in tumor was inversely associated with recurrence, while greater density in normal tissue was positively associated with recurrence. We received a 1- year Extension without Funds (end date 6/30/2016) to be able to complete all tasks for our promising work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2015
- Accession Number
- AD1013488
Entities
People
- Elizabeth A Platz
Organizations
- Johns Hopkins University