Evaluation of NF-B Signaling in T Cells
Abstract
The studies presented in this thesis describe experiments designed to increase our understanding of how T cells transduce activating signals to the transcription factor NF-B, and to better understand the kinetic nature of NF-B signaling. The overarching goals of this thesis are 1) to evaluate T cell receptor mediated activation of the transcription factor NF-B in the absence of key signaling proteins, and 2) to define the mechanisms of signal transduction to NF-B by identifying the point at which signaling becomes digital in nature.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2009
- Accession Number
- AD1013498
Entities
People
- Lara M. Kingeter
Organizations
- Uniformed Services University of the Health Sciences