Clinical Characterization and Imaging of Triggered Attacks in Chronic Migraine and Posttraumatic Headache

Abstract

Chronic posttraumatic headache (PTH) is a disabling disorder that affects millions of individuals worldwide. The Principal Investigators (PIs) of this application proposed to develop human models of PTH by characterizing clinical features and correlated changes in brain activity before and during triggered attacks. The PIs hypothesized that the different headache triggers nitroglycerin (NTG) and prostaglandin E2 (PGE2) would produce different types of headache and would be associated with different patterns of brain metabolism that would reveal fundamental mechanisms of PTH.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2016
Accession Number
AD1013645

Entities

People

  • Andrew Charles
  • Peter Goadsby

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Central Nervous System Diseases
  • Department Of Defense
  • Diseases And Disorders
  • Headache Disorders
  • Liquid Explosives
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Metabolism
  • Nervous System Diseases
  • Neuroimaging
  • Nitroglycerin
  • Pain
  • Positron Emission Tomography
  • Positron Emissions
  • Prostaglandin

Fields of Study

  • Psychology

Readers

  • Cardiovascular Physiology
  • Neurotrauma and Rehabilitation Medicine.
  • Research Science/Academic Research