Use of Isolated Mitochondria and Pulmonary Artery Endothelial Cell Systems in Studies of Oxygen Utilization and the Effects of Hemoglobin-Based Oxygen Carriers

Abstract

Hemoglobin-based oxygen carriers (HBOCs) with various oxygen affinities are currently being evaluated for clinical use. We tested whether HBOCs with high vs. low oxygen affinities can affect molecular oxygen on and offloading, using isolated mitochondria and Bovine Pulmonary Artery Endothelial Cells(BPAECs) as model systems.

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Document Details

Document Type
Technical Report
Publication Date
Jul 16, 2008
Accession Number
AD1013654

Entities

People

  • John E. Karaian

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biomedical And Dental Materials
  • Blood
  • Blood Substitutes
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Free Radicals
  • Health Services
  • Hemorrhagic Shock
  • Measurement
  • Metabolic Diseases
  • Mitochondria
  • Polymeric Films

Fields of Study

  • Biology

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