Sensitivity of Retinal Ganglion Cell Photoreceptors in Traumatic Brain Injury Patients with Photophobia

Abstract

Intolerance to light, or photophobia, is a common symptom in individuals that have experienced traumatic braininjury (TBI). We investigated the light sensitivity of melanopsin-containing retinal ganglion cells in subjects that have had a prior head injury. These intrinsically photosensitive retinal ganglion cells (ipRGCs) act as irradiance detectors and signal information about ambient light levels. 28 subjects with prior TBI and photophobia were recruited for the study, with 24 completing two experimental sessions. 12 age-matched subjects participated in a control group.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
AD1013667

Entities

People

  • Andrew T. Hartwick

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Amplitude
  • Biomedical Research
  • Brain Injuries
  • Data Analysis
  • Department Of Defense
  • Detectors
  • Eye Diseases
  • Fourier Analysis
  • Head Injuries
  • Light Pulses
  • Medical Personnel
  • Observers
  • Photoreceptors
  • Photosensitivity
  • Sensitivity
  • Spreadsheet Software
  • Vision Disorders

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.