The Effect of Traumatic Stress on Multiple Aminergic Systems in the Basolateral Amygdala and Hypothalamus: Specific Impairment of Serotonin 5-HT2a Receptor Signaling and its Pathophysiological Role in an Animal Model of Post Traumatic Stress Disorder
Abstract
The amygdala and hypothalamus are central brain regions participating in stress response. This response also requires participation of multiple aminergic systems, which extensively interconnect with the amygdala and hypothalamus. Thus, dysregulation of aminergic systems, particularly the serotonergic and noradrenergic systems, is closely linked with multiple anxiety and stress disorders. The present study, utilizing a learned helplessness stress model, determined if alterations of aminergic systems in the amygdala and hypothalamus were involved in stress-induced behavioral and physiological abnormalities associated with anxiety and stress disorders.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 27, 2007
- Accession Number
- AD1013996
Entities
People
- Xiaolong Jiang
Organizations
- Uniformed Services University of the Health Sciences