Pregnancy Specific Glycoprotein 23 binds to CD151 and Induces the Secretion of IL-10 and TGF-beta1 in Murine Macrophages

Abstract

Pregnancy-specific glycoproteins are placentally secreted proteins present in the maternal circulation. They are the most abundant fetal protein in late pregnancy and correlate with human pregnancy success. Previously, we identified the tetraspanin CD9 as the receptor for PSG17. This interaction is required for PSG17 mediated anti-inflammatory cytokine production. The present research analyzes the functions and receptor binding of PSG23 in relation to PSG17.

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Document Details

Document Type
Technical Report
Publication Date
Jul 11, 2007
Accession Number
AD1014000

Entities

People

  • Briana L. Johnson

Organizations

  • Uniformed Services University of the Health Sciences

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Animal Structures
  • Blood
  • Cardiovascular System
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Culture Techniques
  • Embryos
  • Epithelial Cells
  • Lymphocytes
  • Peptide Growth Factors
  • Pregnancy Complications
  • Urogenital System

Fields of Study

  • Medicine

Readers

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