Adolescent Rats Differ by Genetic Strain in Response to Nicotine Withdrawal

Abstract

Gender is a powerful predictor of initiation and maintenance of cigarette smoking in adults, but less is known about smoking in adolescents. Thisresearch examined nicotine withdrawal behaviors in 96 adolescent, male and female, Sprague-Dawley (SO) and Long-Evans (LE) rats. Rats received sevendays continuous subcutaneous infusion of saline or nicotine hydrogen tartrate via Alzet osmotic minipumps. Behavioral observations were made before, during,and after saline or nicotine administration. SO male and female rats that received nicotine displayed significantly more withdrawal behaviors one and twodays after cessation of nicotine administration compared with rats that had received saline. LE male rats that received nicotine displayed significantly morewithdrawal behaviors one day (but not two days) after cessation of nicotine administration compared with males that received saline.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2007
Accession Number
AD1014044

Entities

People

  • Michael E. Perry

Organizations

  • Uniformed Services University of the Health Sciences

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DTIC Thesaurus Topics

  • Aneurysm
  • Body Weight
  • Depression
  • Drug Abuse
  • Families (Human)
  • Genetics
  • Health Services
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  • Biology
  • Psychology

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  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
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  • Biotechnology