The Effect of Diazoxide Upon Heat Shock Protein and Physiological Response to Hemorrhagic Shock and Cerebral Stroke

Abstract

Our team tested the hypothesis that pharmacological induction of ischemicpreconditioning (IPC) can offer cytoprotection and preserve vital tissues after cerebralstroke with hemorrhagic shock. The compound, diazoxide (DZ), is known to mimic IPCthrough its effects as a mitochondrial KATP channel opener and succinate dehydrogenaseinhibitor. The effect of DZ was examined under two IPC protocols: delayedpreconditioning and postconditioning in an anesthetized rat model of hemorrhagic shock,combined in some experimental groups with cerebral vascular occlusion (stroke). [truncated]

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Document Details

Document Type
Technical Report
Publication Date
Jun 16, 2006
Accession Number
AD1014226

Entities

People

  • Joseph C. O'sullivan

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel
  • Myocardial Ischemia
  • Proteins

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.