Identification of Associations Between Genetic Factors and Asthma that are Modified by Obesity

Abstract

We performed a genome-wide gene by environment (asthma) interaction analysis for the outcome of body mass index (BMI) in the Multi-Ethnic Study of Atherosclerosis (MESA) (N=2474 Caucasians, 257 asthmatics) and replicated findings in the Framingham Heart Study (FHS) offspring cohort (N=1408 Caucasians, 382 asthmatics). The replicable tagging single nucleotide polymorphism (SNP) rs2107212 was further examined in stratified analyses. Seven SNPs clustered in 17q21.2 were identified to be associated with higher BMI among asthmatics (interaction p < 5 10-7 in MESA and p < 0.05 in FHS). Nominally associated copy number variations interacting with BMI were associated with asthma among African American women in the Womens Health Initiative study.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2016
Accession Number
AD1014445

Entities

People

  • Andrew T. Dewan

Organizations

  • Yale University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • African Americans
  • Air Force
  • Air Force Research Laboratories
  • Cardiovascular Diseases
  • Caucasians
  • Detection
  • Diseases And Disorders
  • Environment
  • Ethnic Groups
  • Factor Analysis
  • Genes
  • Genetics
  • Health
  • Liver Diseases
  • Quality Control
  • Risk Factors
  • Women'S Health

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Neurological Diseases/Conditions/Disorders
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology