Yucatan Miniature Swine as an Animal Model for Dengue-1 Disease

Abstract

Currently there is no animal model for dengue disease. Non-human primates and mice have been useful for vaccine efficacy studies, but they do not reproduce human disease. Yucatan Miniature swine were examined as a novel animal species in which to study dengue virus infection, resultant immune responses, protective efficacy of the immune responses, and signs of illness with the aim of identifying an animal model for dengue disease. [truncated]

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Document Details

Document Type
Technical Report
Publication Date
Dec 15, 2005
Accession Number
AD1014518

Entities

People

  • Jaimie S. Robinson

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Antigens
  • Azo Compounds
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cell Line
  • Cells
  • Dengue
  • Encephalitis
  • Flaviviridae
  • Health Services
  • Hemorrhage
  • Infectious Diseases
  • Lymphocytes
  • Signs And Symptoms
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Trauma Surgery or Emergency Medicine.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology