Pregnancy Specific Glycoprotein 17 Binds to the Extracellular Loop 2 of its Receptor, CD9, and Induces the Secretion of IL-lO, IL-6, PGE2 and TGFbeta1 in Murine Macrophages
Abstract
Pregnancy specific glycoproteins (PSGs) are a family of proteins produced by primate and rodent placentas and secreted into the maternal circulation. In humans PSGs are detected in maternal serum from the time of implantation, and their concentration increases when pregnancy progresses, reaching 200-400 microgram/ml at term. The correlation between low levels of PSGs and poor pregnancy outcomes suggests PSGs play a role in the regulation of maternal immunity to the semi-allogeneic fetus. We have previously reported that human and murine PSGs induce anti inflammatory cytokines in monocytes, and identified CD9 as the cellular receptor form urine PSG17. However, the role of CD9 in cytokine induction mediated by PSG17 as well as the signaling mechanism triggered in macrophages in response to PSG17 remain largely unknown. The present research attempted to shed light on these two areas
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 09, 2004
- Accession Number
- AD1014570
Entities
People
- Cam Thi Ha
Organizations
- Uniformed Services University of the Health Sciences