Pathology Report for Intraperitoneal Sodium Dichromate Exposure in Rats

Abstract

This project was a collaboration between USACEHR and APHC (Div Tox Path) to process and microscopically evaluate kidney and liver tissues from rats intraperitoneally injected with sodium dichromate dihydrate for a project to identify molecular markers in blood or urine that predict or indicate liver and/or kidney injury resulting from exposure to specific metal intoxication. The investigator aims to validate hypothesized adverse outcome pathways in rats exposed to toxic metals to identify less invasive, rapid biomarkers that could be used in early disease progression. Sodium dichromate dihydrate caused persistent inflammation on the peritoneal surface of liver and kidney tissues after a single injection.

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Document Details

Document Type
Technical Report
Publication Date
Aug 12, 2015
Accession Number
AD1014805

Entities

People

  • Erica E. Carroll

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Cells
  • Computers
  • Cytoplasm
  • Disease Attributes
  • Environmental Health
  • Fibrosis
  • Glycogen
  • Health
  • Inspection
  • Medical Personnel
  • Necrosis
  • Observation
  • Pathology
  • Public Health
  • Toxicity
  • Toxicology

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Oncology and Biomarker-Based Cancer Detection.
  • Toxicology/Environmental Toxicology