Pathology Report for One-Generation Study of the Effects of 3-nitro-1,2,4-triazol-5-one (NTO) to the Northern Leopard Frog (lithobates pipiens) Under Static Renewal Test Conditions

Abstract

Larval (tadpole) northern leopard frogs were exposed to 3-nitro-1,2,4-triazol-5-one (NTO) or to water control until they developed into froglets (up to 90 days) at Gosner Stage 46 (Gosner, 1960). Animals were humanely euthanized and kidney and liver tissues examined microscopically to detect indications of toxicity. No evidence of toxicity or developmental delay was observed, suggesting NTO may not affect anuran renal or hepatic development. Tissues did have inflammatory changes normally associated with infection by mycobacteria, fungi or foreign materials.

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Document Details

Document Type
Technical Report
Publication Date
Dec 28, 2015
Accession Number
AD1014810

Entities

People

  • Erica E. Carroll

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Animals
  • Blood Cells
  • Cells
  • Department Of Defense
  • Environment
  • Environmental Protection
  • Germ Cells
  • Health
  • Insensitive Explosives
  • Materials
  • Medical Personnel
  • Public Health
  • Spermatozoa
  • Testes
  • Toxicity

Readers

  • Aquatic Ecology
  • Toxicology/Environmental Toxicology