Brain MR Spectroscopy Biomarkers in a Clinical Trial of PTS Patients With Comorbid AUD

Abstract

This human neuroimaging application builds on the successful high-field neuroimaging program under the umbrella of the longstanding collaboration between the DoD and the Northern California Institute for Research and Education (NCIRE), carried out jointly by investigators of the Center for Imaging of Neurodegenerative Diseases (CIND) and treatment staff from the VA Mental Health Services. Our overall goal is to determine if topiramate facilitates functionally significant adaptive modulation of -aminobutyric acid (GABA) and glutamate levels in the neocortex of 40 alcohol dependent veterans with posttraumatic stress disorder(PTSD). We propose to perform longitudinal proton magnetic resonance spectroscopy (1H MRS) as an addendum to an ongoing double-blind placebo controlled trial of topiramate in the treatment of alcohol dependence in veterans with PTSD. Longitudinal control studies will be conducted in 10 healthy controls. All studies will be performed on a 3T scanner and half the sample will also be scanned on the new 7T scanner to assess its utility in patient research.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2016
Accession Number
AD1014835

Entities

People

  • Dieter J. Meyerhoff

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Anticonvulsants
  • Brain
  • California
  • Clinical Trials
  • Contracts
  • Data Acquisition
  • Data Analysis
  • Databases
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Education
  • Health Services
  • Magnetic Resonance
  • Mental Health
  • Neurodegenerative Diseases

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Neuroscience