A Computational Framework for Design and Development of Novel Prostate Cancer Therapies

Abstract

Tek protein kinases, such as Etk and Btk, play key roles in the survival and proliferation ofprostate cancer cells. We developed novel computational and combinatorial frameworks fordesign and development of small molecule inhibitors targeting Etk. Large scale in silicoscreening of virtual libraries was used to identify novel Etk inhibitors. Experimentalstudies with small-molecule ligands identified from computational screens show promising cellgrowth inhibition for PC3 cells in cell culture based experiments. In addition, we usedphylogenetic and structural studies to identify novel target sites. Overall, thecomputational methods developed here can be used to rapidly scan and develop potent enzymeinhibitors, and more generally provide drug leads for late-stage prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1016350

Entities

People

  • Gaurav Bhardwaj

Organizations

  • University of California, Davis

Tags

DTIC Thesaurus Topics

  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Crystal Structure
  • Gene Expression
  • Health Services
  • Liquid Chromatography
  • Medical Personnel
  • Molecular Dynamics
  • Neoplasms
  • Peptides
  • Prostate Cancer
  • Small Molecules

Fields of Study

  • Biology

Readers

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