Maternal Brain-Reactive Antibodies and Autism Spectrum Disorder

Abstract

We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2; thus this antibody may contribute to approximately 5 of cases of ASD.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1016784

Entities

People

  • Betty Diamond

Organizations

  • The Feinstein Institute for Medical Research

Tags

Communities of Interest

  • Autonomy

DTIC Thesaurus Topics

  • Albumins
  • Autism
  • Autoimmune Diseases
  • Biomedical Research
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Genes
  • Genetics
  • Medical Personnel
  • Neurons
  • Neurosciences
  • Proteins

Fields of Study

  • Biology

Readers

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  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Infectious Disease/Epidemiology