Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

Abstract

Studies in year two have shown that the rat dorsal skin and hind limb burn injury models are appropriate for testing the analgesic and healing rate efficacy of test drugs. These models were used to test Ibuprofen (Ibu), Ibu-PC, Indomethacin (Indo), and Indo-PC. The experimental drug Indo-PC showed a tendency for analgesic efficacy over Indo alone or the Ibu drugs, notably when administered parenterally. These studies support a rationale for continued development of parenteral Indo-PC for treatment of 2nd degree burn wounds.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2016
Accession Number
AD1017031

Entities

People

  • Lenard M. Lichtenberger

Organizations

  • University of Texas Health Science Center at Houston

Tags

DTIC Thesaurus Topics

  • Analgesia
  • Anti-Inflammatory Agents
  • Biomedical Research
  • Burns
  • Cancer
  • Chemotherapeutic Agents
  • Connective Tissue
  • Epidermis
  • Hair
  • Inflammation
  • Membrane Lipids
  • Neoplasms
  • Professional Development
  • Side Effects
  • Skin
  • Test Methods
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Geochemistry
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology