Coexpression of the Follicle Stimulating Hormone Receptor and Stem Cell Markers: A Novel Approach to Target Ovarian Cancer Stem Cells

Abstract

Purpose: The purpose of this project was to determine whether the Follicle-stimulating Hormone Receptor (FSHR) is coexpressedwith a sufficient number of ovarian cancer stem cell markers to consider it as a new experimental target for novelnanotechnology approaches capable of destroying ovarian cancer stem/progenitor cells (OCSCs).Scope: We examined individual cells obtained from ovarian cancer patients to determine whether they expressed recognizedovarian cancer stem cell markers and the FSHR on the surface membrane of the same cell. Cells co-expressing the markersand the FSHR (plus appropriate controls) were then tested in mice to determine whether any tumors formed also co-expressedthe same markers.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2016
Accession Number
AD1017033

Entities

People

  • David W. Schomberg

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Blood
  • Blood Serum
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Demographic Cohorts
  • Membranes
  • Mrna
  • Nanotechnology
  • Neoplasms
  • Ovarian Cancer
  • Proteins
  • Stem Cells
  • Tissues

Fields of Study

  • Biology
  • Medicine
  • Physics

Readers

  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology