New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury

Abstract

We have developed robust low-magnetic-field implementations of MRI (LFI) focused on brain imaging with two complimentary test scanner systems: electromagnet and permanent magnet based. We have also developed injury-sensitive MRI based on the detection of free radicals associated with injury using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI (OMRI). We have optimized imaging sequences, image reconstruction, and parallel imaging based acceleration in this unique regime. Results include demonstration high-speed brain imaging in the electromagnet LFI at 6.5 mT, preliminary3D imaging in a 100 lb scanner based on a rotating permanent magnet array, and improved free-radical OMRI both in vitro and in vivo. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact, transforming diagnosis and monitoring of secondary injury prevalent in TBI.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2016
Accession Number
AD1017186

Entities

People

  • Matthew S. Rosen

Organizations

  • Harvard University

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Brain
  • Brain Injuries
  • Compressed Sensing
  • Detectors
  • Diagnostic Imaging
  • Health Services
  • Magnetic Fields
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Neuroimaging
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Medicine
  • Physics

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.