The Effect of a Third Generation Hemostatic Dressing in a Subclavian Artery and Vein Transection Porcine Model

Abstract

Background: Hemorrhage is the leading cause of preventable battlefield death. Non-compressible injuries to junctional regionsaccount for 20 of these deaths and present a challenge to medical care providers. A novel minisponge-based dressing (MSD), has been developed to control junctional hemorrhage. The MSD is a syringe applicator filled with compressed chitosan coated mini- sponges which are delivered directly into the wound cavity. Initial published results for MSD are promising but further evaluation ofsafety and efficacy is warranted. Methods: In a swine model of uncontrolled junctional hemorrhage by subclavian artery (SCA) and vein(SCV) transection, animals were randomly assigned to three hemostatic dressing treatment groups (n = 10 per group); MSD and standard-of-care hemostatic dressing with and without three minutes of manual compression (SCHD) and (SCHD-NC), respectively. Blood loss was measured during; a 30-second free bleed immediately following injury, dressing application, a 3-4 minute wait period and a 60 minute observation period. Primary endpoints were application time, blood loss, hemostasis, and survival. Statistical significance was determined by one-way ANOVA. Results: Baseline values for weight, blood pressure, hematocrit, injury cavity volume and SCA and SCV diameters, were not different between groups. Blood loss during free-bleed, overall blood loss and hemostasis were also not different between groups. However, pack time and blood loss during application were lower (p<0.05) in the MSD group compared to the SCHD-WC and SCHD-NC groups. Conclusion: No differences in survival, hemostasis or overall blood loss were observed betweenthe three groups, however, application time and blood loss during application were lower with MSD compared to the two SCHD groups.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
AD1017263

Entities

People

  • Antoni Macko
  • Bjorn K. Song
  • Forest R. Sheppard
  • Rene Alvarez

Organizations

  • Naval Medical Research Unit—San Antonio

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anesthesia
  • Applicators
  • Arteries
  • Battlefields
  • Biomedical Research
  • Blood
  • Body Regions
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Combat Casualty Care
  • Compression
  • Health Services
  • Hemorrhage
  • Standards
  • Therapy
  • United States Special Operations Command
  • Veins

Fields of Study

  • Medicine

Readers

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  • Cardiovascular Physiology