The Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers

Abstract

Whole genome sequence (WGS) data are commonly used to design diagnostics for the identification of bacterial pathogens. To do this effectively, genomics databases must be comprehensive to identify the strict core genome that is specific to the target pathogen. As additional genomes are analyzed, the core genome size is reduced and there is erosion of the target-specific regions due to commonality with related species, potentially resulting in the identification of false positives and/or false negatives.

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Document Details

Document Type
Technical Report
Publication Date
Sep 20, 2016
Accession Number
AD1017305

Entities

People

  • Adam J. Vazquez
  • Alex Hutcheson
  • Apichai Tuanyok
  • Carina M. Hall
  • Christopher J. Allender
  • Derek S Sarovich
  • Erin P. Price
  • Galina Koroleva
  • James M. Schupp
  • Jason T. Ladner
  • Jason W. Sahl
  • John S. Lipuma
  • Jonas Korlach
  • Joseph D. Busch
  • Kenzie Shippy
  • Madeline Lummis
  • Mark Mayo
  • Rebecca E Colman
  • Sean Lovett
  • Talima Pearson
  • Vanessa Theobald

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Assembly
  • Australia
  • Biomedical Information Systems
  • Biomedical Research
  • Computational Biology
  • Computer Programming
  • Databases
  • Department Of Defense
  • Genetics
  • Genomics
  • Identification
  • Infectious Diseases
  • Microbial Genetics
  • Microbial Genome
  • Nucleotides
  • Pathogenic Bacteria
  • United States

Fields of Study

  • Biology

Readers

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