Development of Silicon-Coated Superparamagnetic Iron Oxide Nanoparticles for Targeted Molecular Imaging and Hyperthermic Therapy of Prostate Cancer
Abstract
The main goal of the research project is to develop and test a novel class of dual-threat theranostic nanoparticles for targeted imaging and hyperthermic therapy of prostate cancer. These particles consist of both silicon (for hyperpolarized magnetic resonance imaging, MRI) and superparamagnetic iron oxide (for hyperthermic therapy). Preliminary results show that simple mixtures between the two particles still allow for hyperpolarized MRI to take place, albeit with a slightly broadened 29Si NMR lineshape. Six generations of particles have been completed and physically characterized (tunneling electron microscopy, dispersive x-ray spectroscopy, electron spin resonance spectroscopy) to show a viable coupling between the silicon (~300 nm) and iron oxide (~5 nm), with the iron oxide attached to the surface of the silicon. The hybrid particles can be hyperpolarized for enhanced MR signals using Dynamic Nuclear Polarization. A small-scale hyperthermia device that induces therapeutic heating in the nanoparticles has been set up and used to acquire preliminary results.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2016
- Accession Number
- AD1017734
Entities
People
- Bradley Nolan
- Nicholas Whiting
- Susan M. Kauzlarich
Organizations
- University of Texas at Austin