Immunomodulation to Optimize Vascularized Composite Allograft Integration in Limb Loss Therapy

Abstract

Recent improvements in body armor have reduced the rate of combat death but increased the rate of extremity injury, burnand limb loss in surviving casualties. As such, methods to replace injured limbs are increasingly required to support combatservice personnel. Vascularized composite alltransplantation (VCA) has recently emerged as a promising strategy for therepair or replacement of amputated limbs, and novel methods for immune management to prevent the rejection of transplantedtissues are now available that may greatly reduce the risks associated with limb transplantation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
AD1018331

Entities

People

  • Linda C. Cendales

Organizations

  • Emory University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Armor
  • Biomedical Research
  • Body Armor
  • Casualties
  • Composite Materials
  • Department Of Defense
  • Immunomodulation
  • Institutional Review Board
  • Management Personnel
  • Medical Personnel
  • Rejection
  • Therapy
  • Transplantation
  • Transplants

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology