Control of Cellular Structural Networks Through Unstructured Protein Domains

Abstract

The goal of this project is to implement a research program in cellular bioengineering that focuses on hierarchical structural and mechanicalnetworks in cells. The research plan seeks to determine the role of molecularscalesteric forces on the assembly, mechanics, and cellstructural contributions of UPDs. There are three aims: (1) To determine the quantitative relationship between chain phosphorylation andsteric repulsive properties of UPDs in vitro; (2) To experimentally test the hypothesis that altering neurofilament UPD phosphorylation altersmorphology, mechanics, and neurogenesis in neural stem cells; (3) To develop and use multiscale computational modeling approaches torelate cytoskeletal protein phosphorylation to cellular mechanical properties.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2016
Accession Number
AD1018340

Entities

People

  • Sanjay Kumar

Organizations

  • University of California, Berkeley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Bioengineering
  • Biomedical Engineering
  • Cell Movement
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Engineering
  • Measurement
  • Mechanical Properties
  • Mechanics
  • Medical Personnel
  • Multiscale Modeling
  • Proteins
  • Quartz Crystal Microbalances
  • Stem Cells
  • Surface Plasmon Resonance

Readers

  • Defense Technology Research and Development.
  • Molecular and Cellular Biology
  • Neuroscience

Technology Areas

  • Biotechnology