Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Abstract

We report the synthesis and characterization of a water-stable zirconium metal-organic framework(MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

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Document Details

Document Type
Technical Report
Publication Date
Oct 05, 2016
Accession Number
AD1018688

Entities

People

  • Diego A Gómez-Gualdrón
  • Joseph T. Hupp
  • Lu Lin
  • Mark A. Guelta
  • Omar Farha
  • Peng Li
  • Randall Q. Snurr
  • Steven P. Harvey
  • Su-young Moon

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Weapons Technologies

DTIC Thesaurus Topics

  • Buffers (Chemistry)
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Confocal Laser Scanning Microscopy
  • Crystal Structure
  • Crystals
  • Density Functional Theory
  • Electrospray Ionization
  • Mass Spectrometry
  • Materials
  • Measurement
  • Microscopy
  • Nerve Agents
  • Spectra
  • Spectroscopy
  • United States

Readers

  • Analytical Chemistry
  • Nanocomposite Materials Science
  • Neurotoxicology