HGF/c-MET Pathway in AIDS-Related Lymphoma
Abstract
In the first year of funding period, we have almost completed Specific Aim1 subtasks listed in the SOW forms. We also have obtained some promising data for Specific Aim3 subtasks. In summary, we found targeting HGF/c-MET pathway induced KSHV PEL cell apoptosis through cell cycle arrest and DNA damage. The Illumina microarray data indicated that there are much more host factors potentially controlled by the HGF/c-MET pathway within PEL cells than we previously expected. We also found that selective c-METinhibitor can effectively prevent PEL expansion in the xenograft model, although the underlying mechanisms still being further investigated. During this funding period, we have totally published 8 peer-reviewed articles about the molecular mechanisms of KSHVviral oncogenesis, and developing novel therapeutic strategy against these malignancies, including one in BLOOD journal. In all these publications, I serve as the corresponding or co-corresponding author. We also had oral presentation and/or poster display on several national or international meetings. With the support by this DOD award, I recently got a Leukemia Research Foundation pilot funding about the sphing olipid metabolism in AIDS-related lymphomas.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2016
- Accession Number
- AD1020468
Entities
People
- Chris Parsons
- Lu Dai
- Zhiqiang Qin
Organizations
- Louisiana State University System