Quantitative, Noninvasive Imaging of DNA Damage in Vivo of Prostate Cancer Therapy by Transurethral Photoacoustic (TUPA) Imaging
Abstract
The goals of this training grant is to develop the foundations for a new medical imaging modality, now called Trans-Urethral Photoacoustic (TUPA) Imaging, which utilizing a small catheter into the urethra enabling imaging molecular marker of DNA Damage during prostate radiation therapy with high photoacoustic contrast and resolution. The development of this modality is significant to tracking the biologic effect of radiation treatment, rather than just the physical dose1-6. The first-year research goals were to develop the imaging instrumentation to enable this modality. This grant has provided the funding to devise a trans-urethral photoacoustic endoscope, which has the potential to obtain higher resolution by using a high frequency ultrasound detector and achieve deeper penetration depth with a light delivery via the urethra. For the first-year training goals, this grant has provided for extensive study in prostate cancer, molecular imaging modalities, molecular targeting of cancer, and opportunities to engage physicians. After finished the 1st year project at Stanford University (30 SEP 2013 -31 DEC 2014). I have now accepted a tenure-track assistant professor position at The University of Oklahoma officially start from February in 2015.More than 1000 square feet of new lab space was assigned to me at Stephenson Research and Technology Center. I want to finish the DoD prostate cancer project and continue to do research at the new institution. The preparations have been done for transferring this grant from Stanford to The University of Oklahoma: 1000 square feet of lab space is opening at The University of Oklahoma; 1 postdoctoral research fellow was hired; collaboration with Urologist at OUHSC has been build, and the photoacoustic (TUPA) Imaging system has been rebuilt in The University of Oklahoma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2015
- Accession Number
- AD1020565
Entities
People
- Liangzhong Xiang
Organizations
- Stanford University