Imaging Prostate Cancer with Positron Emission Tomography
Abstract
Tumors associated fibroblasts (TAFs) represent a major component of a PCa tumor, and play a critical role in tumor development. The purpose of this proposal is to utilize fibroblast activation protein alpha (FAP) expression on TAFs within the tumor stroma for the diagnostic imaging of PCa using novel radiopharmaceuticals and innovative multimodal imaging platforms. This progress report describes the in vivo biodistribution analysis of radiolabeled FAP conjugates, which are 10-20 fold more potent as FAP inhibitors than similar inhibitory peptides described in the literature. Radiopharmaceutical retention in blood was low at early time points suggesting rapid clearance from the blood pool. Radioactivity was retained in kidney tissue and suggests that this is the primary route of excretion. Tumor targeting was inefficient.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2016
- Accession Number
- AD1020580
Entities
People
- Thaddeus J Wadas
Organizations
- Wake Forest University