Intrathoracic Pressure Regulator for Blood Loss
Abstract
Hemorrhagic shock is a leading cause of death in combat, yet potentially survivable with early intervention. This is especially true in patients with head injury. Resuscitative measures, e.g., fluid therapy, can be lifesaving; however, delays in intravenous access and differential fluid responsiveness result in over- and under-resuscitation. Intrathoracic pressure regulation (ITPR) is an emerging technology used to treat hypovolemia and cardiac arrest. Preclinical trials demonstrate that ITPR increases venous return and thereby restores blood pressure and perfusion. We compared the effect of ITPR to placebo in restoring hemodynamics after hemorrhage under general anesthesia. A secondary aim was to determine if ITPR could reduce the fluid burden of hemorrhage. Based on group-to-group comparisons, ITPR had limited effect on improving mean arterial pressure and other hemodynamic responses. However, in some subjects, when ITPR is implemented, improvement in stroke volume, other indices of perfusion, and volume sparing occurs. While fluid resuscitation is the standard of care in hypovolemic hemorrhagic shock, delays in treatment can be potentially fatal.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2016
- Accession Number
- AD1021102
Entities
People
- Alex Indrokovs
- Aristedes Koutrouvelis
- Dani Solanki
- George C. Kramer
- Husong Li
- Michael Salter
- Mike Kinsky
- Muzna Kahn
- Richard D Branson
- Roger Seeton
- Sheryl Henkel
Organizations
- University of Cincinnati