Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss

Abstract

In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss (NIHL).The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the inner ear that leads to noise-induced hearing loss (NIHL). The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss: mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a localized application procedure to the outer ear canal of a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1021582

Entities

People

  • Alfred L. Nuttall
  • Teresa Wilson

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Demographic Cohorts
  • Dynamics
  • Ear
  • Frequency
  • Hearing Disorders
  • Hearing Loss
  • Inhibition
  • Inhibitors
  • Intervention
  • Measurement
  • Medical Personnel
  • Membranes
  • Molecules
  • Organ Of Corti
  • Small Molecules
  • Steady State

Fields of Study

  • Physics

Readers

  • Acoustics.
  • Cellular and Molecular Pathways of Apoptosis.
  • Neurotrauma and Rehabilitation Medicine.