Bacterial Genome Engineering and Synthetic Biology: Combating Pathogens

Abstract

The emergence and prevalence of multidrug resistant (MDR) pathogenic bacteria poses a serious threat to human and animal health globally. Nosocomial infections and common ailments such as pneumonia, wound, urinary tract, and bloodstream infections are becoming more challenging to treat due to the rapid spread of MDR pathogenic bacteria. According to recent reports by World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), there is an unprecedented increase in the occurrence of MDR infections worldwide. The rise in these infections has generated an economic strain worldwide, prompting the WHO to endorse a global action plan to improve awareness and understanding of antimicrobial resistance. This health crisis necessitates an immediate action to target the underlying mechanisms of drug resistance in bacteria.

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Document Details

Document Type
Technical Report
Publication Date
Nov 04, 2016
Accession Number
AD1021620

Entities

People

  • Richard T. Moore

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Bacterial Infections
  • Bacteriology
  • Cell Physiological Processes
  • Health Services
  • Infection
  • Infectious Diseases
  • Medical Personnel
  • Microbial Genome
  • Microbiology
  • Microbiomes
  • Mrna
  • Pathogenic Bacteria
  • Synthetic Biology
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Infectious Disease/Epidemiology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology