The Multiple Inert Gas Elimination Technique: A User's Manual
Abstract
The Multiple Inert Gas Elimination Technique (MIGET) is a method of assessing ventilation/perfusion (VA/Q) inequalities, shunt, and diffusion limitation. It was initially developed as a means of quantifying VA/Q mismatch as an intrapulmonary cause of hypoxemia. The lung is viewed as a set of 50 respiratory units, each with a distinctive VA/Q ratio. Six inert gases of varying solubility in blood are infused, and the arterial and expired gas concentrations of the gases are measured under steady-state conditions. Then, distribution of blood flow and ventilation to each of the 50 compartments is calculated. Although technically challenging, this method can be applied in a wide range of basic and clinical settings, and enables the evaluation of VA/Q mismatch in a relatively low-risk, non-invasive fashion. This report describes the MIGET methodology from a technical standpoint, as currently performed at the U.S. Army Institute of Surgical Research (USAISR). General set up, assessment of gas chromatograph (GC) linearity, preparation and infusion of the 6-gas solution, specimen collection and processing, and data analysis are covered in detail. Creation of a novel, complex, multi-ramped GC program is described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 11, 2016
- Accession Number
- AD1021903
Entities
People
- Alexander T. Dixon
- Andriy I Batchinsky
- Brendan M Beely
- Bryan S. Jordan
- Leopoldo C. Cancio
Organizations
- United States Army Institute of Surgical Research