Modular Bioconjugates to Study Herceptin Resistance: A Structural and Functional Approach

Abstract

The focus of the studies described herein was to apply the developed antibody-capsid conjugates to both the examination of ultra structural features relevant to invadopodia formation as well as mass cytometry probes for the analysis of signaling dynamics in Herceptin resistance development. In working to achieve these goals, a number of challenges were encountered, and the experimental details and assessments are described in the attached report.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1022013

Entities

People

  • Adel Elsohly

Organizations

  • University of California, Berkeley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Biomolecules
  • Blood
  • Blood Proteins
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Liquid Chromatography
  • Mass Spectrometry
  • Materials Science
  • Metallic Nanoparticles
  • Molecules
  • Polymers
  • Proteins
  • Resistance
  • United States
  • X-Ray Computed Tomography

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