FDA approved Immunosuppressants Targeting Staphylococcal Superantigens: Mechanisms and Insights
Abstract
Immunostimulating staphylococcal enterotoxin B (SEB) and related super antigenic toxins cause diseases in humans and laboratory animals by hyperactivating cells of the immune system. These protein toxins bind to the major histocompatibility complex (MHC) class II molecules and specific VP regions of T-cell receptors (TCR), resulting in stimulation of bothmonocytes/macrophages and T lymphocytes. The bridging of TCR with MHC class II molecules by superantigens triggers intracellular signaling cascades, resulting in excessive release of proinflammatory mediators and massive polyclonal T-cell proliferation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 02, 2016
- Accession Number
- AD1022226
Entities
People
- Teresa Krakauer
Organizations
- United States Army Medical Research Institute of Infectious Diseases