Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (P-REBOA) in a Pig Model (Sus scrota)
Abstract
Objectives: We investigated the hemodynamic and physiologic effects of partial Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) versus the current practiced complete REBOA (c-REBOA) technique. Methods: Fifteen Yorkshire-cross swine were subjected to 25% total blood volume loss. They were randomized to either c-REBOA, p-REBOA, or no intervention. Aortic pressures, visceral arterial pressures, and serum makers of ischemia were recorded throughout the experiment. P-REBOA was achieved by inflating the balloon catheter to generate a 50% pressure gradient across the balloon. Following balloon deflation, the experiment continued for 15 minutes to evaluate the effects of reperfusion. End organs were histologically examined. Results: Compared with no treatment, c-REBOA produced considerable increases in central aortic pressure after hemorrhage but also substantially higher levels of serum lactate, followed by a precipitous drop in blood pressures on balloon deflation. p-REBOA resulted in hemodynamic effects that were superior to control while maintaining a similar lactate profile. Histological analysis of intestinal mucosa revealed early necrosis and disruption of the villi with c-REBOA, but not in the p-REBOA and control group. Conclusion: p-REBOA may minimize the systemic physiologic insult and damage to tissues distal to the balloon .
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 14, 2015
- Accession Number
- AD1022767
Entities
People
- Lucas Neff