Identifying Subgroups of Tinnitus Using Novel Resting State fMRI Biomarkers and Cluster Analysis

Abstract

The subject of the project is FY14 PRMRP Topic Area - Tinnitus. The broad goal of this project is to link behavioral measures of tinnitus severity to brain imaging scans that target areas of auditory, attention, and emotion processing, which are important to the underlying neural mechanisms of tinnitus. This study uses functional magnetic resonance imaging (fMRI) and is taking place at the University of Illinois at Urbana-Champaign (UIUC) for civilian data collection (patient and control) and at Wilford Hall Ambulatory Surgical Center (WHASC) for military data collection (patient and control). Identical audiological, behavioral, and brain imaging protocols are being used at both sites and include patients with a range of tinnitus severity. In Year 1, we have begun to use resting-state fMRI to identify measurable characteristics of functional connectivity in attention, emotion, and auditory processing networks that are exclusive to the tinnitus population. In Year 2, we will use clustering algorithms applied to the resting-state data to identify tinnitus subgroups within the patient population and pair them with specific behavioral characteristics.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2016
Accession Number
AD1023983

Entities

People

  • Fatima T Husain

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Active Duty
  • Biological Markers
  • Brain
  • Clustering
  • Computer Programming
  • Data Acquisition
  • Data Analysis
  • Illinois
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Neuroimaging
  • Professional Development
  • Resonance
  • Students
  • Universities

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Medical or Health Care Field.
  • Neurotrauma and Rehabilitation Medicine.