A Multiplex Cancer/Testis Antigen-Based Biomarker Panel to Predict the Aggressive Phenotype of Prostate Cancer

Abstract

The Cancer/Testis Antigens (CTAs) are a group of proteins normally confined to germ cells but aberrantly expressed in several cancers. The central hypothesis of this grant application is that a CTA-based biomarker can be used to discern LPCa from MPCa. In the first year of this grant, we determined gene expression of 22 candidate CTAs by Nanostring and validated by qRT-PCR. During the second year of the grant, we used ROC curve analysis and identified 8 CTA genes (CEP55, NUF2,PAGE4, PBK, RQCD1, SPAG4, SSX2 and TTK), which expression pattern is significant different between aggressive and indolent tumors.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2016
Accession Number
AD1023997

Entities

People

  • Robert W. Veltri

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biological Markers
  • Biological Staining And Labeling
  • Biomedical Research
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Frequency
  • Gene Expression
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Regression Analysis
  • Statistical Analysis
  • Tissues

Fields of Study

  • Biology

Readers

  • Educational Psychology
  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • AI & ML